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Pernicious anemia - OBGYN Associates
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Our Health Library information does not replace the advice of a doctor. Please be advised that this information is made available to assist our patients to learn more about their health. Our providers may not see and/or treat all topics found herein.

Pernicious anemia

Pernicious anemia is a blood disease caused by the lack of a substance (intrinsic factor) that the body needs in order to absorb vitamin B12 from food. Without enough vitamin B12, the body does not produce enough red blood cells, and cells throughout the body do not get the oxygen they need.

In pernicious anemia, the body produces antibodies that either destroy the parietal cells (cells in the stomach that make intrinsic factor) or that block the action of intrinsic factor. A doctor can diagnose this disease by doing a blood test that looks for these antibodies.

Symptoms include weakness, numbness in the hands and feet, loss of appetite, weight loss, and fever. Pernicious anemia can damage the nerve cells in the brain and spinal column.

The treatment for pernicious anemia is supplements of vitamin B12. These may be given as shots, pills, or a nasal spray. Because the body can no longer absorb this vitamin from food, the supplements must be continued for life.

Pernicious anemia can happen at any age. But the chances of getting it increase as people get older.

Current as of: December 13, 2023

Author: Ignite Healthwise, LLC Staff

Clinical Review Board
All Healthwise education is reviewed by a team that includes physicians, nurses, advanced practitioners, registered dieticians, and other healthcare professionals.